pentobarbital will lessen the level or impact of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; stay away from use in patients who're chronically using a powerful CYP3A4 inducerpentobarbital will lessen the extent or influence of diazepa